tdm
  a R package for therapeutic drug monitoring

Simulation :
We validated
this tools using simulated date obtained from the mean PK parameters within the range of 2*sd. And the accuracy of PK parameters was validated with percent prediction error (PE%) . And there are two ways to produce simulated data. In first validation if drug A monitored Cl and Vd, we simulated them obtained from Cl-2*sd plus Vd-2*sd to Cl+2*sd plus Vd+2*sd ; In another validation we simulated PK parameters obtained with mean Cl plus mean Vd within the range of 2*sd or with mean Vd plus mean Cl within the range of 2*sd.
Validation Result :
   Validation I
cl validation od tdm

Table 1
Validation I of Clearance as Percent of Prediction Error


















vd validation I of tdm Table 2
Validation I of Volume of Distribution (%PE)








Validation I of Absorption Rate Constant (%PE) Table 3
Validation I of Absorption Rate Constant (%PE)




Validation I of PK Parameters of Phenytoin (%PE)
 * Vmax: maximum rate of metabolism
 * Km: plawma concentration at which metabolism is occuring at half the maximum rate

Table 4
Validation I of PK Parameters of Phenytoin (%PE)



 * Cmax: concentration related with maximum suppression of clotting factors
 * cl: clearance
 * K: first order rate constant for clotting factor degradation
 * m: prothrombin complex activity remaining
 * Vd: volume of distribution
Table 5
Validation I of PK Parameters of Warfarin (%PE)









  Validation II


 * Cl mean + Vd sd represents tdm is validated with mean cl plus mean vd within the range of 2*sd
 * Cl sd + Vd mean represents tdm is validated with mean cl within the range of 2*sd plus mean Vd


Table 6
Validation II of Clearance and Volume of Distribution (%PE)










Table 7
Validation II of PK parameters of Ritonavir (%PE)




Table 8
Validation II of PK parameters of Enfuvirtide (%PE)


Table 9
Validation II of PK parameters of Indinavir (%PE)


 * Vmax: maximum rate of metabolism
 * Km: plasma concentration at which metabolism is occurring at half the maximum rate

Table 10
Validation II of PK parameters of Phenytoin (%PE)


 * Cmax: concentration related with maximum suppression of clotting factors
 * cl: clearance
 * K: first order rate constant for clotting factor degradation
 * m: prothrombin complex activity remaining
 * vd: volume of distribution

Table 11
Validation II of PK parameters of Warfarin (%PE)