tdm
  a R package for therapeutic drug monitoring
Algorithms: The core of tdm used to estimate individual PK parameters is based on OpenBugs (an Open-source BUGS, Bayesian Inference Using Gibbs Sampler with Markov Chain Monte Carlo Integration).
Features:
 1.
17 drugs models including 16 PK models and one PK/PD model (warfarin): including aminoglycoside, carbamazepine, cyclosporine, digoxin, enfuvirtide, everolimus, indinavir, lithium salt form, phenytoin, ritonavir, tacrolimus, theophylline salt form, vancomycin, Imatinib, enoxaparin, and warfarin
 2.
using an MCMC Bayesian method
3.
function of dose adjustment
4.
freeware under GPL
5.
diagnostic plots such as density, auto-correction and history plots
6.
only Windows NT/XP platform because BRugs only run under Windows OS
Graphical PK models of tdm:

ss graphical PK model of BUGS

 

mm graphical PK model of BUGS

Figure 1 - Graphical Model Used to Estimate multiple Subjects' PK parameters of Vancomycin with Each Single Serum Concentration   Figure 2 - Graphical Model Used to Estimate Multiple Subjects' PK parameters of Vancomycin with Multiple Concentrations
Comparing Characteristics of tdm with Other Desktop-type Clinical Pharmacokinetic Software1 
Program
Version reviewed
No. of drugs
supported
Bayesian model
Platform
supported
Price
N/A 2
5 3
Yes
MS-Win
$100 4
$200 5
N/A 6
2 7
Yes
MS-Win
$100 5
$250 8
N/A 9
23
Yes
MS-Win
$25 10
$20 11
5.0.14
8
No
MS-Win
$740
N/A12
8
Yes
MS-Win
$700
5.0.0
7
Yes
MS-Win
N/A 13
1.2.5
2
No
MS-Win
$100
6.5.1
9
Yes
MS-Win
$1200 14
$600 15
11.7
11
Yes
DOS
$595 16
$895 17
3.0
 15 18
Yes
MS-Win/
Mac OS X/
Linux
Free
1.2.1
17
Yes
MS-Win
Free
1. Surveyed before Feb., 2007; 2. The version number of Kinetics is not available at Kinetics website; 3. Not including a database of over 100 drugs based on Bennett's tables or a one-compartment model of renal excreted drugs; 4. Personal use license for Windows; 5. Single seat license for Windows; 6. The version number of Kinetics is not available at APK website; 7. Not including one-compartment modeling of renal excreted drugs; 8. Site (network) license for Windows; 9. The version number of Kinetics is not available at Antibiotic Kinetics website; 10. For a single license; 11. Per seat if multiple licenses purchased; 12. The version number is not available at CAPCIL website; 13. The price of kinetidex is not available at Kinetidex website; 14. The price of T.D.M.S. for new Subscribers (includes 1 year of free updates); 15. The price of T.D.M.S. for Annual License Renewal; 16. Academic license; 17. Commercial license; 18. Only numbers of built-in models.

Comparing Built-in Drugs in tdm and Other Desktop-type Clinical Pharmacokinetic Software1
Drug
Amikacin
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Carbamazepine
                 
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Cyclosporin
                 
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Digoxin
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ˇ
ˇ
   
ˇ
ˇ
 
ˇ
ˇ
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Digoxin +
Quinidine
               
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Digitoxin
               
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Enfuvirtide
                 
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Everolimus
                 
ˇ
ˇ
Gentamicin
ˇ
ˇ
ˇ
ˇ
ˇ
ˇ
ˇ
ˇ
ˇ
ˇ
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Heparin
   
ˇ
               
Indinavir
                 
ˇ
ˇ
Lidocaine
ˇ
             
ˇ
   
Lithium
                 
ˇ
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Netilmicin
 
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ˇ
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Phenobarbital
             
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Phenytoin
 
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Quinidine
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Ritonavir
                 
ˇ
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Tacrolimus
                 
ˇ
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Theophylline
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ˇ
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Tobramycin
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Trimethoprim
               
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Vancomycin
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Valproic acid
         
ˇ
     
ˇ
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Warfarin
                 
ˇ
ˇ
1. Surveyed before Feb.28,2007; 2. Not including a database of over 100 drugs