tdm
  an R package for therapeutic drug monitoring
Download and how to install:
1.
Before you want to install tdm , you have to Install R  first from R website.
   - Click CRAN on the left-hand side of R website and choose one of CRAN mirror that you like
   - Click "Window (95 and later)" version
   - Click "base" to download install R (such as R-2.4.1-win32.exe)
   - Double click on the file that you just download to install R
2.
 After installation of R, execute it and you can see menu list of "File, Edit, Misc, Packages, Window, Help" on the top of R console window. Click option of package and install package.
3.
Choose a mirror that is close to you and then you can choose "tdm" package to install.
4.
After installation, start tdm by typing "library(tdm)" in R console.
Update History:
Version
Date
Update Log
2.1.1 11-20-2007 this version fixed warfarin problem that caused system hold when running it on R v2.6.0 with newly released BRugs. Also the function of multiple subjects with single dataset was removed in this version.
 
2.1.0 11-04-2007 This version fixed warfarin algorithm to work successfully with BRugs 0.4-1.
 
2.0.0 08-23-2007 Source codes of tdm were simplified for working effectively. For digoxin, models for pediatrics were removed, because models for adult also worked for estimating pediatric PK parameters. Considering using conveniently, function of summary outputs was removed.
 
1.2.1 07-09-2007 For better estimation results (smaller prediction errors than before), this version fixed theophylline salt form (IR tablet, iv infusion) and imatinib mesylate algorithms. Besides, settings of indinaivr were also modified again.
 
1.1.0 05-11-2007 For better estimation results (smaller prediction errors than before), this version fixed aminoglycoside, theophylline IR, imatinib mesylate and enoxaparin algorithms.  Besides, settings of Indinaivr and Enfuvirtide were also modified.  New function of summary outputs including individual information, estimated PK parameters with or without dose adjustment is displayed, and user can select them and save as a txt file.  Theophylline iv fusion has not been provided any more because it is unnecessary in practice. We also fixed some bugs including calculations of mm model and some interpretations.   Dose adjustment after calculating mm (estimate multiple subjects with multiple concentrations) data type was removed.
 
1.0.0 11-02-2006 First version of tdm is released in R website.