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>>
Poster for The 2004 PSROC Annual Meeting,
Taipei, TAIWAN (ROC)
download from
here (PDF)
Algorithms
Validation Using Simulated Data
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Methods
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Comments
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Sawchuk-Zaske Method
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This part is validated with simulated data
using MS-Excel spreadsheet. We are
not going to show the result of validation.
You can do this yourself if you like.
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Bayesian Individualized
Estimation |
See the following Table.
The best way is to test mobilePK yourself:
using simulated data (for example phenytoin, with daily Dose/kg/day
(Ro), Vmax
and Km values be ready and then you calculate Cp at steady-state
ready; then run mobilePK and select phenytoin and give Ro, Cp to mobilePK.
See if you can get similar results as we
did.)
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|
%PE |
gentamicin
|
vancomycin
|
digoxin
|
cyclosporin-A
|
%PE |
phenytoin
|
|
Cl |
-4.64
|
3.71
|
6.03
|
0 |
Vmax
|
-3.57
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|
Vd |
5.04
|
-0.594
|
- |
- |
Km
|
-5.34
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|
C* |
2.47
|
-2.08
|
-4.24
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0 |
Css
|
5.16
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*: gentamicin & vancomycin: drug concentration at a certain time
during steady-state (Cs).
digoxin: drug concentration at a certain time during steady-state (Css).
Now %PE of digoxin is much
smaller than previous
version since v2.2.
cyclosporin-A: trough concentration at steady-state (Ct).
%PE: mean percentage of prediction error (N = 6).
-: not used in the model.
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For phenytoin PK:
mobilePK vs.
diagram estimation method using Vozeh's contour plot (Vozeh et al., 1981) (click
to view big-sized pictures); please
note Vozeh's contour plot does not allow users to estimate PK
parameters
when phenytoin serum concentration is greater than 20
mcg/mL. Point values (at the red-cross mark) in the
contour
plot were
"read" using a small but very nice program called
GetData®
Graph Digitizer.
(click
to enlarge this picture)
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RUNs
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#1
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#2
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#3
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#4
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#5
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#6
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Ro (mg/kg/day) |
2.00
|
2.00
|
5.00
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5.00
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10.0
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10.0
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Cpss (μg/mL) |
2.00
|
4.00
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6.00
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18.0
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15.0
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20.0
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Vmax (mg/kg/day)
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(mobilePK)
|
7.08
|
5.63
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7.83
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6.37
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10.3
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10.6
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|
Vmax
(mg/kg/day) |
(Vozeh)
|
7.06
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5.91
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8.19
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6.39
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12.2
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11.7
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|
PE of Vmax |
0.020
|
0.280
|
0.360
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0.020
|
1.90
|
1.10
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Km (mcg/mL)
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(mobilePK)
|
4.74
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6.24
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3.46
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4.90
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0.445
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1.17
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Km (mcg/mL)
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(Vozeh)
|
4.87
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7.59
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3.75
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5.08
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3.19
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3.28
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PE
of Km |
0.130
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1.35
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0.290
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0.180
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2.75
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2.11
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assumed: patient's body weight is
60 kg; male
PE: prediction error
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Comparison
of mobilePK® with Other Similar Tools That Have Been Available in Clinical PK*
(Only for Mobile
Devices, e.g. Palm OS-based PDA, Pocket PC, Mobile Phones)
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Program
|
AbPK |
ICUmath |
KineticsPro |
PKCalc |
ClinRx |
mobilePK
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|
TDM
Provided |
Amikacin |
Amikacin |
Amikacin |
Amikacin |
Amikacin |
Amikacin |
|
Gentamicin |
Gentamicin |
Gentamicin |
Gentamicin |
Gentamicin |
Gentamicin |
|
Tobramycin |
Tobramycin |
Tobramycin |
Tobramycin |
Tobramycin |
Tobramycin |
|
Vancomycin |
Vancomycin |
Vancomycin |
Vancomycin |
Vancomycin |
Vancomycin |
|
Netilmicin |
Digoxin |
|
|
|
Digoxin |
|
Kanamycin |
|
|
|
|
Phenytoin |
|
|
|
|
|
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Cyclosporin-A |
|
|
|
|
|
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Warfarin |
|
|
|
|
|
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Theophylline,
Lithium &
Carbamazepine
New! |
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Bayesian
Method (?) |
Yes |
No |
No |
No |
No |
Yes |
Devices
Supported |
Palm OS
PDAs &
Pocket PCs |
Palm III &
Palm OS v3 |
Palm OS v5 |
Palm OS PDAs (v3) |
Pocket PCs,
Palm OS v5 |
Palm OS v4 PDA,
Palm OS v5 Tréo
series Smartphones,
Java-supported cell
phones/Smartphones,
Pocket PCs, Windows
Mobiles v5 or 2003 &
compatible
Smartphones |
|
Price (USD) |
25
(single lic.) |
free |
19.95 |
24.95 |
20
(single lic.) |
free |
|
*: Surveyed on Jan. 12, 2007.
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