RSS Builder by B!Soft mobilePK - A TDM Tool for Mobile Devices http://pkpd.kmu.edu.tw/mobilepk/ mobilePK (formerly JavaPK for Mobiles) is a clinical pharmacokinetic (or therapeutic drug monitoring, TDM) tool for mobile devices including PalmOS v5 PDA phones (Tréo series, p/w), SymbianOS Java-supported mobile phones or smartphones (incl. Motorola, Nokia, BlackBerry and Sony Ericsson), and Pocket PCs or smartphones (WM2003 and WM5/WM6). mobilePK was written in Java (Java ME, JDK v6.0 with NetBeans IDE v5.5.1 plus NetBeans Mobility CLDC), and was the first clinical pharmacokinetic program in the world running on mobile phones (with CLDC v1.0 and MIDP v2.0 or above). It was built with Sawchuk-Zaske method (aminoglycosides and vancomycin), Chiou method (theophylline iv inf.) and Bayesian estimation method (gentamicin, tobramyin, amikacin, vancomycin, digoxin, phenytoin, cyclosporin-A, lithium, carbamazepine, theophylline and warfarin). With Bayesian estimation, one can use only one blood sample (at steady-state) to estimate individual pharmacokinetic parameters at steady-state. And now we are have a similar program running different platforms running on Mac OS X, WinXP Desktop PC, and Linux-based PC (Fedora Core 3/4/5). Please check with JPKD® (formerly JavaPK® for Desktop). Try it before Purchasing: mobilePK® is a shareware, and you can freely test the program for 30 days after installation. See the following section of "Purchase mobilePK®". Algorithms: Algorithms used to calculate individual pharmacokinetic parameters are based on Sawchuk-Zaske method, Chiou method (for theophylline iv inf. only) and Bayesian estimation. en-us mobilePK@gmail.com mobilePK@gmail.com PharmDataTech, Taiwan, 2003-2008 (c) We moved again. Wed, 30 Apr 2008 15:25:11 +0800 http://pkpd.kmu.edu.tw/mobilepk/ mobilePK@gmail.com news update Free registration site is ready now. Mon, 24 Dec 2007 17:38:30 +0800 http://pkpd.kmu.edu.tw/register mobilePK@gmail.com update
  • We have finished the website for free registration for mobilePK v6.
  •  Please click http://register.pkpd.org.tw for free registration.
  • The 30-day trial function has been removed since it was for shareware version.  Now mobilePK has been freeware.  We don't need that.  However, users must register mobilePK before using it.
  • Season greeting:- Merry Christmas and Happy New Year for 2008!
    • ]]>         Cannot install mobilePK v6? Tue, 18 Dec 2007 16:34:49 +0800 http://pkpd.kmu.edu.tw/mobilepk/ mobilePK@gmail.com update  Ooops!  Sorry about that some users may not be able to install successfully with mobilePK v6 as provided on Dec. 17, 2007.  Don't be panic.  We just accidentally used Java ME with MIDP v2.1 to compile mobilePK v6.  That causes problem!   Some mobile devices only support up to MIDP v2, not v2.1.  So the installation is not possible as a result.  Now we have already fixed this.  Just go back to MIDP v2.  That's it. Please re-download the file again and re-install it.  It works now.  Promised.:-)  We still keep the same version number (v6).  Basically, all algorithms are remained the same. That's why we don't give a new version number for it.  For some websites, they will need a new version number for updated files upload.  Don't know why.  But we have to get used to it.  We will say it v6.1, if it is the case.  As the matter of the fact, it is not.  mobilePK for BlackBerry (BB) mobiles should be no such problem since BB's IDE has not supported MIDP v2.1 yet.  That's very interesting, too.  And don't know why, either.]]> mobilePK is freeware now! Mon, 10 Dec 2007 17:55:41 +0800 http://pkpd.kmu.edu.tw/mobilepk/ mobilePK@gmail.com news update Yes, Freeware! Since the first release of mobilePK (formerly JavaPK for mobile Devices) on Nov. 11, 2004, we had a wonderful time to maintain it, to answer questions from our users and to watch it growing up day by day.   More and more users are choosing mobilePK now.  Since the team becomes busy right now, we decide to let it go as freeware.  Maybe, we should release more, such as an open-source.  The reason we decide to do this doesn't mean that we will not maintain mobilePK later.  On the contrary, we will still maintain it actively, because we just love to.  Thank you for choosing mobilePK.]]> mobilePK v5.5 file updates Sun, 9 Dec 2007 01:14:05 +0800 http://pkpd.kmu.edu.tw/mobilepk/download.html mobilePK@gmail.com file update mobilePK v5.5 released. Wed, 5 Dec 2007 18:18:58 +0800 http://pkpd.kmu.edu.tw/mobilepk/ mobilePK@gmail.com update
  • Phenytoin non-steady state estimation - with an ode solver in this newly developed algorithm; please don't input too many days (Ts < 7 days is recommended) on it.  It may take huge time to complete calculation.  Lu YH spent a lot of efforts on this ode solver.
  • Limitations for some input function; such as the daily dose of phenytoin should be less than 600 mg. Let us know if there is any inappropriateness for all drugs in mobilePK.
  • Ref. values for some drugs have been fixed, too.
  • also, many other updates.
    • ]]>         mobilePK v5.5? when? Tue, 16 Oct 2007 17:10:15 +0800 http://pkpd.kmu.edu.tw/mobilepk/ mobilePK@gmai.com new release PocketPC WM6 Phone tested and mobilePK works well. Wed, 6 Jun 2007 03:47:14 +0800 http://pkpd.kmu.edu.tw/mobilepk/ mobilePK@gmail.com news The test on Windows Mobile professional v6 on my Dopod (htc now) CHT 9000 (a 3G cellular phone, same as htc 836pro) has been completed.  mobilePK works on WM6, too.  In WM6, MIDlet Manager is still there and bundled.]]> a small bug for BlackBerry Mobiles fixed Thu, 10 May 2007 03:45:57 +0800 http://pkpd.kmu.edu.tw/mobilepk/ mobilePK@gmail.com news A little bug finally has been fixed with mobilePK for BlackBerry Mobiles ONLY.  This bug was about the switching problem between input options, such as gender (female or male), smoking (yes, no), CHF (yes, no), etc..  The previous version cannot be correctly switch back and forth between provided options.  It was something going wrong in BlackBerry IDE (v4.2.0) that we used to compile mobilePK of previous version.  The new release BlackBerry IDE v4.2.1 does not have such problem.  Thus, for all BlackBerry users, please download mobilePK again, and re-install it on your device.  However, it still remains the same version# (v5.1), although we have already re-compiled mobilePK for all devices.  Don't worry about this problem with previous calculations.  It will not cause serious mistake for final PK parameter estimation since these options are only to provide 'good' initial values of PK parameters for further Bayesian estimation.  Bayesian estimation is a robust method to give you correct PK parameters with final estimates.  Believe it or not?  Now you can try it yourself with your own data.]]> mobilePK v5.1 released. Thu, 3 May 2007 03:44:35 +0800 http://pkpd.kmu.edu.tw/mobilepk/ mobilePK@gmail.com news While we are improving phenytoin algorithm, we still decide to release this version (5.1) urgently.  This version fixed lithium algorithm for better estimation results (smaller prediction errors than before).  Next version with improved phenytoin algorithm (can be used to estimate Vmax & Km under no steady-state) will released together with JPKD v3.  It is supposed to be soon. ]]> phenytoin new model defined with ODE now... Thu, 8 Mar 2007 03:43:29 +0800 http://pkpd.kmu.edu.tw/mobilepk/ mobilePK@gmail.com update YH (Hero) starts working with a phenytoin ode model now. This model will allow to estimate both Vmax & Km parameters when users cannot assure if its steady-state (SS) has reached or not.  This approach may also estimate PK parameters of phenytoin much earlier under non-steady state than that we have to wait until SS.  It can take a long, long time to reach SS for phenytoin. It's really difficult to estimate time required to reach SS for phenytoin.  In many situations, to assume that SS has already reached may not be reasonable or justified.]]> CAB file for WM2003/WM5 Fri, 2 Mar 2007 03:42:33 +0800 http://pkpd.kmu.edu.tw/mobilepk/ mobilePK@gmail.com update fix both the setup file and CAB files for PPC or WM2003/WM5 (re-uploaded).  It works now.]]> mobilePK v5 released Thu, 1 Mar 2007 03:41:19 +0800 http://pkpd.kmu.edu.tw/mobilepk/ mobilePK@gmail.com update mobilePK v5 released; carbamazepine, lithium & theophylline (Chiou method & Bayesian) have been added; cyclosporin A algorithm has been fixed also; some algorithms ported from JavaPK for Desktop (incl. UDBM) have been modified; a must-be upgrade ver.; see also 'Update Log' of 02-27-2007 for more details.]]> Has a new name - mobilePK now Tue, 27 Feb 2007 03:39:28 +0800 http://pkpd.kmu.edu.tw/mobilepk/ mobilePK@gmail.com update JavaPK for Mobiles has got a new name!  Now it is called mobilePK.  But we will still use its old name "JavaPK" around for a while to allow our users get used to it.  The new version has been ready to release.  Next version will jump to version 5 and will include more TDM drugs in this new release.  Theophylline (Chiou method, Bayesian, and also IR & SR oral dosage forms), lithium and carbamazepine have been added.  One bad news is that the version 5 will no longer run on PalmOS 4 PDA due to increased the required memories (no more than 64 K only!).  So we will keep mobilePK as it was in v3.1.  Don't worry about this.  All registered users of PalmOS v4 PDA can be upgraded to another types of mobile devices for FREE. So this is supposed to be a good news. What about version 4?  Uhh... there was version 4 indeed, but it was not released officially.  Please feel free to contact me. ]]> v31. released. Tue, 2 Jan 2007 03:38:33 +0800 http://pkpd.kmu.edu.tw/mobilepk/ mobilePK@gmail.com update v3.1 released. fix some functions in graphic plots (MTC and MEC lines) and more accurate than before; to integrate all ref. into "Help" button for each built-in drug. And now the register's name will appear in the ticker from this upgrade.]]> a minor bug fixed. Thu, 30 Nov 2006 03:36:00 +0800 http://pkpd.kmu.edu.tw/mobilepk/ mobilePK@gmail.com update fix a bugs of the warfarin model for the "Help" <-> "Input data" screen switching back-and-forth bug; but still remained the same version #.]]> JavaPK for Mobiles v3 released. Wed, 29 Nov 2006 19:45:47 +0800 http://pkpd.kmu.edu.tw/mobilepk/ mobilePK@gmail.com http://clinicaltrial.kmu.edu.tw/upload/yjlee_form_en.html ipdate
  • 11-29-2006: v3.0 released.
    1. A warfarin PK/PD model (Ref.) has been added in this version.
        Dose <-> INR prediction.
    2. A major fix for the function of "input data", especially for
        cell/mobile phones/samrtphone users, has been done. Now no
        need to switch from "alphabetic" mode ('abc') to "numeric" mode
        ('123') frequently any more. I have found a solution for this.
        However, it is only for MIDP v2.0 cell/mobile phones ONLY.
        Fortunately, MIDP v1.0 cell/mobile phones have been out of sale
        for now. A must-be update version. Users need to re-download
        the most updated version from our server since Nov. 29, 2006
        (Taiwan local time).
  • 11-27-2006: We choose "JavaPK for Mobiles" as the new program name.
  • 11-23-2006: The first version for Palm OS v5 or above tested with a PalmOne Treo 650 Smartphone (Palm OS v5.4). v2.5a.
    • ]]>         JavaPK for BlackBerry Mobiles is released! Mon, 6 Nov 2006 20:09:12 +0800 http://pkpd.kmu.edu.tw/mobilepk/ mobilePK@gmail.com update news The first version JavaPK for BlackBerry Mobiles was released.  Yes, it's v2.5a.]]> JavaPK for Mobile Devices v2.5a released Thu, 5 Oct 2006 17:58:43 +0800 http://pkpd.kmu.edu.tw/mobilepk/ mobilePK@gmail.com update news
  • fixed "Phenytoin" dosage adjustment (D --> C; when Dosing Rate > Vmax, in case to accidentally input such a daily dose...);
  • fixed redundant decimal points for the error message of "Phenytoin" Dosage adjustment (D -> C).
    • ]]>         JavaPK for Mobile Devices v2.2 released Tue, 4 Jul 2006 19:26:48 +0800 http://pkpd.kmu.edu.tw/mobilepk/ mobilePK@gmail.com update JavaPK for Desktop v1.0 has been released. Fri, 17 Feb 2006 17:56:06 +0800 http://pkpd.kmu.edu.tw/mobilepk/ mobilePK@gmail.com http://mobilepk.pkpd.org.tw new version news JavaPK for Desktop (JPKD) is a clinical pharmacokinetic (CPK) services (or therapeutic drug monitoring, TDM) computer program for desktop. It not only inherits all functionalities of JavaPK for Mobile Devices, but also has a built- in algorithm of user's defined Bayesian model for individualized pharmacokinetic parameter estimation (UDBM) for batch input data.  Users can define their own pharmacokinetic prediction models with population PK parameters and then use the defined model to solve batch prediction data or applied the defined model to therapeutic drug monitoring (TDM).]]> JavaPK website has been moved... Mon, 6 Feb 2006 11:08:34 +0800 http://pkpd.kmu.edu.tw/mobilepk/ mobilePK@gmail.com http://pkpd.kmu.edu.tw/mobilepk/ news update http://javapk.pkpd.org.tw. Please change your bookmark for the new website. Thanks.]]> JavaPK for Mobile Devices v2.1 released Tue, 3 Jan 2006 10:24:04 +0800 http://pkpd.kmu.edu.tw/mobilepk/ mobilePK@gmail.com update
  • v2.1: fix bugs in vancomycin Bayesian algorithm; actually we changed the population parameters for vanco Bayesian based on recently published research article.
    • ]]>         JavaPK for Desktop Sat, 26 Nov 2005 15:17:08 +0800 http://pkpd.kmu.edu.tw/mobilepk/ mobilePK@gmail.com new software (preview)

    (a standalone program) is our another ongoing project, which will not only inherit all functionalities of JavaPK for Mobile Devices (here is its some built-in Bayesian models), but also will build in algorithm of user's defined Bayesian individualized pharmacokinetic parameter estimation for batch input data.View the demo of this function (avi).  Parameter prediction with non-steady state conc. has been implemented. More drugs such as carbamazepine, theophylline, lithium, immunosuppresants (tacrolimus and everolimus) and some anti-HIV drugs (indinavir, ritonavir and enfluvirtide) will also be added in this version.  Users can define their own model with Bayesian algorithm to predict individual PK parameters.  We include some examples for the users' Bayesian define models (enoxaparin, imatinib mesylate, sirolimus and valproic acid).  Here are some .pdf output files (test.pdf, budm.pdf and output.csv) generated by JavaPK for Desktop.  User's define Bayesian Model can now be converted for the purpose of TDM.  Here is the demo (.swf) for this new feature.  JavaPK for Desktop will be able to run on any JVM supported platform.  This project is being conducted by Mr. Jian-ming Lai.  It is scheduled to be released on Feb., 2006 (postponed).  JavaPK for Desktop will be a donateware (donationware).

    ]]>         compare to other tools? Thu, 27 Oct 2005 17:28:27 +0800 http://www.rxkinetics.com/palm_compare.html mobilePK@gmail.com news Comparison of Antibiotic Kinetics to other PDA pk programs by Rick Tharp, 1103 S. Oak Street, Plattsburg, MO 64477]]> Update History of JavaPK for Mobile Devices Thu, 27 Oct 2005 13:36:11 +0800 http://pkpd.kmu.edu.tw/mobilepk/ yjlee_kmu@yahoo.com.tw news
  • v2.0f: released on Oct. 14, 2005. update cyclosporin-A Bayesian estimation algorithm.
  • v2.0c: released on Sept. 05, 2005. some bugs fixed with algorithms of aminolgycosides and vancomycin.
  • v2.0a: fixed the limit of the peak conc. of vancomycin in graph plot mode. We have moved to http://ce.kmu.edu.tw/JavaPK.htm since August 1, 2005.
  • v2.0: some algorithms updated; sampling times (including peak or trough Cp at steady-state with Sawchuk-Zaske method, and Cs with Bayesian method at the steady-state) for all aminoglycosides (gentamicin, amikacin, tobramycin and amikacin) and vancomycin are counted from the end time of i.v. infusion, NOT the starting time of i.v. infusion (it was counted from the starting time of i.v. infusion with the previous version); the unit of Cl for digoxin Bayesian has been changed to L/hr (it was L/hr/kg before).
  • v1.0b: algorithms updates.
    • ]]>         What's new in v2.0f? Wed, 26 Oct 2005 03:36:09 +0800 http://pkpd.kmu.edu.tw/mobilepk/ mobilePK@gmail.com update
  •  v2.0f: released on Oct. 14, 2005. update cyclosporin-A Bayesian estimation algorithm.
    • ]]>         Announcing RSS/XML news for JavaPK Wed, 26 Oct 2005 03:30:36 +0800 http://pkpd.kmu.edu.tw/mobilepk/ mobilePK@gmail.com News JavaPK has been moved to a new site Mon, 1 Aug 2005 18:46:35 +0800 http://pkpd.kmu.edu.tw/mobilepk/ mobilePK@gmail.com news http://ce.kmu.edu.tw/JavaPK.htm)!]]>