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JPKD

JPKD (formerly JavaPK for Desktop) is a clinical pharmacokinetic (CPK) services (or therapeutic drug monitoring, TDM) computer program for desktop. It is the first pharmacokinetic (PK) program which allows users to define their own Bayesian PK estimation model using published population PK parameters, and the defined model can be easily and directly applied to the dosage adjustment of TDM. JPKD is not just like mobilePK. It includes many features that mobilePK dose not have.
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JPKD is freeware under GPL>2 since June 30, 2013.
News

US FDA updates Coumadin(r) (warfarin) labeling
2007-08-16 The following message is quoted from FDA website.
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Warfarin (marketed as Coumadin)
Audience: Hematologists, other healthcare providers, consumers
[Posted 08/16/2007] FDA approved updated labeling to include pharmacogenomics information to the CLINICAL PHARMACOLOGY, PRECAUTIONS, and DOSAGE AND ADMINISTRATION sections of the prescribing information for the widely used blood-thinning drug, Coumadin. This new information explains that people's genetic makeup may influence how they respond to the drug. Specifically, people with variations in two genes may need lower warfarin doses than people without these genetic variations. The two genes are called CYP2C9 and VKORC1. The CYP2C9 gene is involved in the breakdown (metabolism) of warfarin and the VKORC1 gene helps regulate the ability of warfarin to prevent blood from clotting.

The dosage and administration of warfarin must be individualized for each patient according to the particular patient's prothrombin time (PT) / International Normalized Ratio (INR) response to the drug. The specific dose recommendations are described in the warfarin product labeling, along with the new information regarding the impact of genetic information upon the initial dose and the response to warfarin. Ongoing warfarin therapy should be guided by continued INR monitoring.

[August 16, 2007 - Drug Information Page - FDA]
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Fixed a bug of Digoxin's model file
2007-07-05 Fixed a bug of Digoxin's model file
--> Digoxin's model file: Download it!
JPKD v3 released.
2007-05-04 JPKD v3 has been taking a long time to release. Mostly, we took a lot time on phenytoin with non-SS conc. estimation with an ode solving algorithm and add-on of NG tube feeding. Others, such as cyclosporin-A, lithium, digoxin and many other UDBMs, were also included.  YH spent a lot time on this revised JPKD to implement an ode solver for non-SS conc. of phenytoin. NG tube feeding is the first try to add-on since NG tube will significantly decease phenytoin bioavailability. We are very happy to have Ms. Chen, MT (Ruby) joining us now. She's been working very hard on her tdm for R right now, and also on her MS thesis (time to graduate). This version is a must-be upgrade.
Plan to change 'JavaPK for Desktop' to JPKD & the release version 3
2007-03-23 It has been long time that we have not revised JavaPK for Desktop. However, We still work very hard to improve it. The version 3 has been ready to released as scheduled. Best wish, YJ
Fixed two bugs of Cyclosporin-A's and Lithium's model files respectively
2007-03-23 Fixed two bugs of Cyclosporin-A's and Lithium's model files respectively.
--> Cyclosporin-A model file: Download it!!
--> Lithium model file: Download it!!
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