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JPKD
 JPKD (used to be JavaPK for Desktop) is a computer program for clinical pharmacokinetic (CPK) services (or therapeutic drug monitoring, TDM). It not only inherits all functions of mobilePK, but also has a built-in algorithm of user's defined Bayesian model for individualized pharmacokinetic parameter estimation (UDBM) for both batch input data and application to TDM. Users can define their own pharmacokinetic prediction models with population PK parameters, and then use the defined model to solve batch prediction data or applied the defined model to TDM.
Disclaimer
JPKD is created for your own personal uses and testing purposes only. JPKD shall be always used as a guide or a decision support tool. Medical decisions should NOT be solely based on the results of this program. Although this program has been tested thoroughly, the accuracy of the information cannot be guaranteed. Once you use JPKD, you have automatically agreed with this disclaimer.
Features
  • Sawchuk-Zaske (aminoglycosides & vancomycin), Chiou method (Theophylline) and Bayesian method for PK parameter estimation
  • 15 built-in drugs for TDM (see the below drug lists)
  • functions for users defined Bayesian estimation drug models
  • portable function for users' defined models
  • a built-in spread sheet for batch PK parameter estimation & input data manipulation
  • application user-defined Bayesian model to TDM
  • multiple desktop platforms (WinXP/NT, Mac OS X, Linux PC) supported
Built-in drug lists
  • Amikacin
  • Carbamazepine
  • Cyclosporin
  • Digoxin
  • Enfuvirtide
  • Everolimus
  • Gentamicin
  • Indinavir
  • Lithium
  • Phenytoin
  • Ritonavir
  • Tacrolimus
  • Theophylline (IR, CR and IV infusion)
  • Tobramycin
  • Vancomycin

Comparing Characteristics in JPKD and Other Desktop-type Clinical Pharmacokinetic Software1

Program
Version reviewed
No. of drugs supported
Bayesian model
Platform supported
Price
 N/A 2
 5 3
Yes
Win
$100 4
$200 5
 N/A 6
 2 7
Yes
Win
$100 5
$250 8
 N/A 9
 2 7
Yes
Win
$25 10
$20 11
 N/A12
8
Yes
Win
$700
5.0.14
8
No
Win
$740
5.0.0
7
Yes
Win
 N/A 13
1.2.5
2
No
Win
$100
6.5.1
9
Yes
Win
$1200 14
$600 15
11.7
11
Yes
DOS
$595 16
$895 17
1.0.0
17
Yes
Win
Free
1.0
  15 18
Yes
Win/
Mac OS X/
Linux
Free

1. Surveyed before March 14, 2007
2. The version number of Kinetics is not available at Kinetics website
3. Not including a database of over 100 drugs based on Bennetts tables or a one-compartment model of renally excreted drugs
4. Personal use license for Windows
5. Single seat license for Windows
6. The version number of Kinetics is not available at APK website
7. Not including -compartment modeling of renally excreted drugs
8. Site (network) license for Windows
9. The version number of Kinetics is not available at Antibiotic Kinetics website
10. For a single license
11. Per seat if multiple licenses purchased
12. The version number is not available at CAPCIL website
13. The price of kinetidex is not available at Kinetidex website
14. The price of T.D.M.S. for new Subscribers (includes 1 year of free updates)
15. The price of T.D.M.S. for Annual License Renewal
16. Academic license
17. Commercial license
18. Only numbers of built-in models

Comparing Built-in Drugs in JPKD and Other Desktop-type Clinical Pharmacokinetic Softwarea

Drug
Amikacin
 
Carbamazepine
 
 
 
 
 
 
 
 
 
Cyclosporin
 
 
 
 
 
 
 
 
 
Digoxin
 
Digoxin+
Quinidine
 
 
 
 
 
 
 
 
 
 
Digitoxin
 
 
 
 
 
 
 
 
 
 
Enfuvirtide
 
 
 
 
 
 
 
 
 
Everolimus
 
 
 
 
 
 
 
 
 
Gentamicin
Heparin
 
 
 
 
 
 
 
 
 
 
Indinavir
 
 
 
 
 
 
 
 
 
Lidocaine
 
 
 
 
 
 
 
 
 
Lithium
 
 
 
 
 
 
 
 
 
Netilmicin
 
 
 
 
 
 
 
 
Phenobarbital
 
 
 
 
 
 
 
 
 
 
Phenytoin
 
 
 
 
 
 
 
 
Quinidine
 
 
 
 
 
 
 
 
Ritonavir
 
 
 
 
 
 
 
 
 
Tacrolimus
 
 
 
 
 
 
 
 
 
Theophylline
 
Tobramycin
 
Trimethoprim
 
 
 
 
 
 
 
 
 
 
Vancomycin
Valproic acid
 
 
 
 
 
 
 
 
Warfarin

a. Surveyed before March 14, 2007
b. Not including a database of over 100 drugs