JPKD RSS News

File with list of functions and operators for users' defined models

jpkd@gmail.com — Wed, 3 Oct 2007 16:01:21 +0800

This text file included all available operators and functions that can be used to build user's defined models. We may consider to include this text file into later JPKD version. For users who may want to download this text file, please click here. You can right click the mouse and select "Save as..." to download it.

FDA Clears Genetic Lab Test for Warfarin Sensitivity

jpkd@gmail.com — Wed, 3 Oct 2007 16:00:04 +0800

Again, from FDA website
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The U.S. Food and Drug Administration today cleared for marketing a new genetic test that will help physicians assess whether a patient may be especially sensitive to the blood-thinning drug warfarin (Coumadin), which is used to prevent potentially fatal clots in blood vessels...

One-third of patients receiving warfarin metabolize it quite differently than expected and experience a higher risk of bleeding. Research has shown that some of the unexpected response to warfarin depends on variants of two genes, CYP2C9 and VKORC1. The Nanosphere Verigene Warfarin Metabolism Nucleic Acid Test detects some variants of both genes...

Warfarin is the second most common drug, after insulin, implicated in emergency room visits for adverse drug events...(more)

How to use JPKD to estimate warfarin PK/PD parameters

jpkd@gmail.com — Sun, 16 Sep 2007 01:54:47 +0800

Open JPKD and move the Tab on the top to the right and click "UDBM --> TDM"; and
then click "Select one" pulldown menu and select "Warfarin_pkpd". Here is a Flash demo.
Please note that JPKD's warfarin algorithm has not supported genotyping yet.

FDA Encourages Genetics-Aided Warfarin Dosing

jpkd@gmail.com — Sun, 16 Sep 2007 01:54:04 +0800

Quoted from AJHP News.
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BETHESDA, MD, 14 September 2007 — The addition of pharmacogenomic information to the official dosage recommendations for warfarin, a widely used drug, "means that personalized medicine is no longer an abstract concept but has moved into the mainstream," an FDA official declared August 16... more
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two warfarin dosing websites: www.WarfarinDosing.org (web-based) and WarfDocs. (both web-based and PalmOS platforms). Try it yourself...

about user's defined model files

jpkd@gmail.com — Thu, 13 Sep 2007 01:53:05 +0800

Please note that we have updated the user's defined model files bundled with new version of JPKD. So if you re-install a new version of JPKD, you don't have to re-download these model files again. However, since we continue updating these user's defined model files, you will need to re-download the model files which are updated after the released date of the new version JPKD. Basically, JPKD will not delete the user's defined model files created by your own (not bundled). However, we like to suggest that you should always backup your own model file from time to time.

US FDA updates Coumadin(r) (warfarin) labelling

jpkd@gmail.com — Thu, 16 Aug 2007 01:52:03 +0800

The following message is quoted from FDA website.
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Warfarin (marketed as Coumadin)
Audience: Hematologists, other healthcare providers, consumers
[Posted 08/16/2007] FDA approved updated labeling to include pharmacogenomics information to the CLINICAL PHARMACOLOGY, PRECAUTIONS, and DOSAGE AND ADMINISTRATION sections of the prescribing information for the widely used blood-thinning drug, Coumadin. This new information explains that people's genetic makeup may influence how they respond to the drug. Specifically, people with variations in two genes may need lower warfarin doses than people without these genetic variations. The two genes are called CYP2C9 and VKORC1. The CYP2C9 gene is involved in the breakdown (metabolism) of warfarin and the VKORC1 gene helps regulate the ability of warfarin to prevent blood from clotting.

The dosage and administration of warfarin must be individualized for each patient according to the particular patient's prothrombin time (PT) / International Normalized Ratio (INR) response to the drug. The specific dose recommendations are described in the warfarin product labeling, along with the new information regarding the impact of genetic information upon the initial dose and the response to warfarin. Ongoing warfarin therapy should be guided by continued INR monitoring.

[August 16, 2007 - Drug Information Page - FDA]
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JPKD RSS news is back now!

jpkd@gmail.com — Sun, 26 Aug 2007 04:18:43 +0800

Hi, we are back now. Hopefully the news is still new. We promise to update this rss news in the future.

Fixed a bug of Digoxin's model file

jpkd@gmail.com — Thu, 5 Jul 2007 04:01:45 +0800

Fixed a bug of Digoxin's model file
--> Digoxin's model file: Download it!!

JPKD v3 released.

jpkd@gmail.com — Fri, 4 May 2007 04:00:59 +0800

JPKD v3 has been taking a long time to release. Mostly, we took a lot time on phenytoin with non-SS conc. estimation with an ode solving algorithm and add-on of NG tube feeding. Others, such as cyclosporin-A, lithium, digoxin and many other UDBMs, were also included. YH spent a lot time on this revised JPKD to implement an ode solver for non-SS conc. of phenytoin. NG tube feeding is the first try to add-on since NG tube will significantly decease phenytoin bioavailability. We are very happy to have Ms. Chen, MT (Ruby) joining us now. She's been working very hard on her tdm for R right now, and also on her MS thesis (time to graduate). This version is a must-be upgrade.

Plan to change 'JavaPK for Desktop' to JPKD & the release version 3

jpkd@gmail.com — Fri, 23 Mar 2007 03:59:25 +0800

It has been long time that we have not revised JavaPK for Desktop. However, We still work very hard to improve it. The version 3 has been ready to released as scheduled. Best wish, YJ

Fixed two bugs of Cyclosporin-A's and Lithium's model files respectively

jpkd@gmail.com — Fri, 23 Mar 2007 03:58:05 +0800

Fixed two bugs of Cyclosporin-A's and Lithium's model files respectively.
--> Cyclosporin-A model file: Download it!!
--> Lithium model file: Download it!!

Adding a new model of theophylline IV infusion

jpkd@gmail.com — Tue, 23 Jan 2007 03:56:36 +0800

Adding a new model of theophylline IV infusion. Download it!

an user defined model - warfarin released.

jpkd@gmail.com — Tue, 31 Oct 2006 03:55:18 +0800

Adding a new PKPD model file of Wafarin. ("Warfarin_pkpd"). Download it!

JavaPk for Desktop 2.5 release

JavaPK for Desktop News — Sun, 8 Oct 2006 18:45:59 +0800

JavaPK for Desktop 2.5.1008 release. Release note

Adding a new digoxin model file

JavaPK for Desktop News — Wed, 19 Jul 2006 11:52:39 +0800

A new model of digoxin. This model (Digoxin_2002) incorporates more covariates than the built-in model ("Digoxin"). Download it!

JavaPk for Desktop 2.1 release

JavaPK for Desktop News — Wed, 5 Jul 2006 18:45:59 +0800

JavaPK for Desktop 2.1.0705 release. Release note
Fixed model file of "Digoxin". Download it!

JavaPk for Desktop 2.0 release

JavaPK for Desktop News — Tue, 30 May 2006 16:52:06 +0800

JavaPK for Desktop 2.0.0530 release. Release note
Adding "Example and explanation of model file" more...

JavaPK for Desktop 1.2 release

JavaPK for Desktop News — Mon, 15 May 2006 14:23:02 +0800

JavaPK for Desktop 1.2 release Fixed bugs of lithium Bayesian algorithm.

Add some video demos

JavaPK for Desktop News — Thu, 4 May 2006 20:02:47 +0800

Adding some video demos. go to video demo

New version available.

JavaPK for Desktop News — Wed, 3 May 2006 15:53:22 +0800

JavaPK for Desktop 1.1.0503 release. Releas note
Adding a new way to update JPKD. more...
New model file- Theophylline. Download it!

New model file- Theophylline.

JavaPK for Desktop News — Wed, 3 May 2006 10:41:13 +0800

Theophylline model is provided for download now. This model is also an example of using "if statment" to define PK parameters.

JavaPK for Desktop 1.1 release

JavaPK for Desktop News — Mon, 1 May 2006 16:02:26 +0800

1. We changed the default s.d. to 50% of population PK parameter in user-defined model if the s.d. is not set.

2. Fixed a error of drug name in used-defined model. The "Indanavir" model should be named as "Indinavir".

Fixed a bug of the everolimus's model file

JavaPK for Desktop News — Mon, 3 Apr 2006 15:59:41 +0800

Fixed a bug of everolimus. Please replace "Everolimus" in the "UDM" folder with this fixed model file.

Fixed a bug of the aminoglycosides's model file

JavaPK for Desktop News — Thu, 23 Feb 2006 17:03:56 +0800

Fixed a bug of aminoglycosides. Please replace "Aminoglycosides" in the "UDM" folder with this fixed model file.

JavaPK for Desktop 1.0 release

JavaPK for Desktop News — Thu, 23 Feb 2006 16:58:36 +0800

JavaPK for Desktop(JPKD) 1.0 had been released.
JavaPK for Desktop (JPKD) is a clinical pharmacokinetic (CPK) services (or therapeutic drug monitoring, TDM) computer program for desktop. It is the first pharmacokinetic (PK) program which allows users to define their own Bayesian PK estimation model using published population PK parameters, and the defined model can be easily and directly applied to the dosage adjustment of TDM.
You can download JPKD at http://jpkd.pkpd.org.tw/download.htm