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JPKD

JPKD (formerly JavaPK for Desktop) is a clinical pharmacokinetic (CPK) services (or therapeutic drug monitoring, TDM) computer program for desktop. It is the first pharmacokinetic (PK) program which allows users to define their own Bayesian PK estimation model using published population PK parameters, and the defined model can be easily and directly applied to the dosage adjustment of TDM. JPKD is not just like mobilePK. It includes many features that mobilePK dose not have.
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JPKD is freeware under GPL>2 since June 30, 2013.
News

How to define your own model?
2007-10-03 This text file included all available operators and functions that can be used to build user's defined models. For users who may want to download this text file, please click here. You can right click the mouse and select "Save as..." to download it.   We may consider to include this text file into later JPKD version.
FDA Clears Genetic Lab Test for Warfarin Sensitivity
2007-09-19 Again, from FDA website
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The U.S. Food and Drug Administration today cleared for marketing a new genetic test that will help physicians assess whether a patient may be especially sensitive to the blood-thinning drug warfarin (Coumadin), which is used to prevent potentially fatal clots in blood vessels...

One-third of patients receiving warfarin metabolize it quite differently than expected and experience a higher risk of bleeding. Research has shown that some of the unexpected response to warfarin depends on variants of two genes, CYP2C9 and VKORC1. The Nanosphere Verigene Warfarin Metabolism Nucleic Acid Test detects some variants of both genes...

Warfarin is the second most common drug, after insulin, implicated in emergency room visits for adverse drug events...(more)

How to use JPKD to estimate warfarin PK/PD parameters
2007-09-16
  • Open JPKD and move the Tab on the top to the right and click "UDBM --> TDM"; and
  • then click "Select one" pulldown menu and select "Warfarin_pkpd". Here is a Flash demo.
  • Please note that JPKD's warfarin algorithm has not supported genotyping yet.

    FDA Encourages Genetics-Aided Warfarin Dosing
    2007-09-16 Quoted from AJHP News.
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    BETHESDA, MD, 14 September 2007 — The addition of pharmacogenomic information to the official dosage recommendations for warfarin, a widely used drug, "means that personalized medicine is no longer an abstract concept but has moved into the mainstream," an FDA official declared August 16... more
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    two warfarin dosing websites: www.WarfarinDosing.org (web-based) and WarfDocs. (both web-based and PalmOS platforms). Try it yourself...
    about user's defined model files
    2007-09-13 Please note that we have updated the user's defined model files bundled with new version of JPKD. So if you re-install a new version of JPKD, you don't have to re-download these model files again. However, since we continue updating these user's defined model files, you will need to re-download the model files which are updated after the released date of the new version JPKD. Basically, JPKD will not delete the user's defined model files created by your own (not bundled). However, we like to suggest that you should always backup your own model file from time to time.
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